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關於課程

這是為期兩個學期介紹性課程的第一學期課程，重點是關於有機化學結構和機制現有理論、其歷史發展,基礎實驗觀察。該課程開放的對像是那些在化學和物理方面有充分準備分新生，它的目的是發展對原始科學的欣賞力和創新性研究所需的技能知識。

About the Course

This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.
關於J. 邁克爾麥克布萊德教授

J. Michael McBride是耶魯大學的化學學院Richard M. Colgate教授。在伍斯特學院和哈佛大學完成研究生工作之後教授McBride 獲得了哈佛大學物理有機化學博士學位。他於1966年加入耶魯大學化學學院，研究晶體生長和有機固體中的反應。他的獎項包括Prelog 獎章、 畢業院校諾貝爾獎得主簽名獎和本科教育化學製造商協會組織的催化劑大獎。

About Professor J. Michael McBride

J. Michael McBride is the Richard M. Colgate Professor of Chemistry at Yale University. After undergraduate work at the College of Wooster and Harvard College Professor McBride earned a Ph.D. in physical organic chemistry at Harvard University. He joined the Yale Chemistry faculty in 1966, where he studies crystal growth and reactions in organic solids. His awards include the Prelog Medal, the Nobel Laureate Signature Award in Graduate Education, and the Catalyst Award of the Chemical Manufacturers Association for undergraduate education.

課程安排

1.你如何知道的？
2.力學定律，路易斯結構與共振
3.雙極小值、 Earnshaw定理和Plum-Puddings
4.掃描探針顯微鏡
5.x 射線衍射
6.由電子密度差理解鍵
7.量子力學動能
8.一維波函數
9.克尼拉圖形和單電子原子
10.現實與軌道近似
11.軌道矯正與湯姆生原子模型
12.重迭和原子對鍵
13.重迭和能量匹配
14.用XH3檢查雜化理論
15.化學反應活性：單佔分子軌道，最高佔有分子軌道和最低未佔分子軌道
16.識別官能團
17.反應監測和羰基反應性
18.氨基化合物，羧酸和烷基鋰
19.氧氣與化學革命（從開始到1789）
20.原子理論的興起 (1790-1805)
21.從伯齊利厄斯到李比希和維勒（1805-1832）
22.自由基型理論 (1832年-1850)
23. 化學價理論與組成結構（1858）
24.通過同分異構體的數量確定化學結構(1869)
25.三維空間中的模型（1869-1877）：光學異構體
26.範霍夫的碳四面體及手性
27.分子結構的書面表達
28.立體化學命名 ；消旋和分解
29.製備單一對映體和旋光的機理
30.藥物測試與用途：以艾美拉唑為例
31.單一對映異構體的製備與構象能
32.Stereotopicity 與拜爾應變理論
33.構象能與分子力學
34.sharpless 氧化催化劑和環烷烴的構象
35.通過標準鍵了解分子結構與能量
36.鍵能，玻爾茲曼係數與熵
37.勢能面，過渡態理論與反應機理

Class Sessions

1. How Do You Know?
2. Force Laws, Lewis Structures and Resonance
3. Double Minima, Earnshaw's Theorem, and Plum-Puddings
4. Coping with Smallness and Scanning Probe Microscopy
5. X-Ray Diffraction
6. Seeing Bonds by Electron Difference Density
7. Quantum Mechanical Kinetic Energy
8. One-Dimensional Wave Functions
9. Chladni Figures and One-Electron Atoms
10. Reality and the Orbital Approximation
11. Orbital Correction and Plum-Pudding Molecules
12. Overlap and Atom-Pair Bonds
13. Overlap and Energy-Match
14. Checking Hybridization Theory with XH3
15. Chemical Reactivity: SOMO, HOMO, and LUMO
16. Recognizing Functional Groups
17. Reaction Analogies and Carbonyl Reactivity
18. Amide, Carboxylic Acid and Alkyl Lithium
19. Oxygen and the Chemical Revolution (Beginning to 1789)
20. Rise of the Atomic Theory (1790-1805)
21. Berzelius to Liebig and W?hler (1805-1832)
22. Radical and Type Theories (1832-1850)
23. Valence Theory and Constitutional Structure (1858)
24. Determining Chemical Structure by Isomer Counting (1869)
25. Models in 3D Space (1869-1877); Optical Isomers
26. Van't Hoff's Tetrahedral Carbon and Chirality
27. Communicating Molecular Structure in Diagrams and Words
28. Stereochemical Nomenclature; Racemization and Resolution
29. Preparing Single Enantiomers and the Mechanism of Optical Rotation
30. Esomeprazole as an Example of Drug Testing and Usage
31. Preparing Single Enantiomers and Conformational Energy
32. Stereotopicity and Baeyer Strain Theory
33. Conformational Energy and Molecular Mechanics
34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
35. Understanding Molecular Structure and Energy through Standard Bonds
36. Bond Energies, the Boltzmann Factor and Entropy
37. Potential Energy Surfaces, Transition State Theory and Reaction Mechanism